Abstract

COMPARISON OF ANTI-DIABETIC POTENTIAL OF POLYHERBAL FORMULATIONS DIAB-SALACIA CAPSULE, DIA-FREE CAPSULE, AND BGR-34 TABLET

Anushka Singh*, Dr. Bhanu P. S. Sagar, Dr. Amrita Singh

Abstract

The aim of the current study is to compare the anti-diabetic and antioxidant properties of many polyherbal formulations, including BGR-34 Tablet (BGR-34), Diab-Salacia Capsule (DSC), Dia-Free Capsule (DFC) against diabetic wistar rats that were given STZ. It is found that BGR-34 contain 34 SPMs from 06 plants, DSC contains 14 SPMs from 02 plants while DFC contains 42 SPMs from 06 herbal plants. All polyherbal formulations confirmed phenolic compounds, terpenoids, steroids, reducing sugars, glycosides, phytosterols. With increasing concentrations, the BGR-34, DFC and DSC all exhibited higher free radical-scavenging activity. BGR-34 exhibited the highest capacity for NO scavenging. The reducing power of BGR-34, DSC and DFC increased with increasing dosage. BGR-34, DFC and DSC have produced significant anti-diabetic effect in all treatment groups. BGR-34, DFC and DSC had alleviated glucose level. BGR-34, DFC and DSC had induced maximum reduction was observed after 21 days. Furthermore, BGR-34, DFC and DSC had a significant therapeutic benefit on the HDL level in the animals that were treated. BGR-34 and DFC had a therapeutically beneficial VLDL-lowering effect on cholesterol levels. BGR-34 and DFC had a therapeutically beneficial VLDL-lowering effect on cholesterol levels. Finally, BGR-34, DFC, and DSC induced antioxidant activity through significant superoxide radical scavenging activity, inhibition of lipid oxidation, by protecting glutathione in liver. Through the inhibition of cell membrane oxidation, all polyherbal formulations generated strong antioxidant activity in a dose-dependent manner. BGR-34, DFC, and DSC produced antioxidant activity dose dependently by preventing membrane oxidation.

Keywords: Antioxidant, Anti-diabetic glutathione, hypolipidemic, lipid oxidation, radical-scavenging, superoxide.