Abstract

COMPARATIVE ANTI-INFLAMMATORY ACTIVITY OF POLYHERBAL FORMULATIONS VELFLEX SYRUP, PEEDAANT SYRUP, AND FLEXCUS ORTHOCARE SYRUP IN ALBINO WISTAR RATS

Supriya Yadav*, Dr. Amrita Singh, Dr. Bhanu P. S. Sagar

Abstract

In present research investigation, an attempt to conduct in-vitro antioxidant activity, and finally in-vivo anti-inflammatory activity of polyherbal formulations Juncus Flexcus Orthocare Syrup (JFOS; Juncus Life Sciences Private Limited), Vritikas Peedaant Syrup (VPS; Swastik natural) and Velflex Syrup (VS; Velnex medicare india private limited) against Carageenan. JFOS contains 120 SPMs from 19 medical plants, VPS has 112 SPMs from 17 natural herbs, and Polyherbal formulation VS has 93 SPMs from 25 medicinal plants. In contrast, JFOS, VPS, and VS are all scientifically established compositions. The polyherbal formulation JFOS was discovered to contain a relatively higher quantity of TPC and TFC than VPS or VS. Additionally, there was a direct correlation between the concentrations of VS, VPS, and JFOS and their antioxidant activity. NO scavenging activity was higher in JFOS. As the dosage of JFOS, VPS, and VS increased, so did their reducing power (they have anti-oxidant and free radical scavenging properties). JFOS and VPS were discovered to have extremely strong antioxidant activity using the FRAP assay. In-vivo antiinflammatory activity indicated that treatment with the standard, polyherbal formulations JFOS, VPS and VS treated animals showed improved edema inhibition at the 5-hour observation. Further, anti-inflammatory effects of polyherbal formulations JFOS was more significant than anti- inflammatory effects of polyherbal formulations VPS and VS. Finally, anti-inflammatory effects of polyherbal formulations JFOS, VPS and VS were less significant than standard reference drug i.e. Diclofenac.

Keywords: Anti-inflammatory, antioxidant, free radical scavenging, polyherbal, total phenolic content, total flavonoid content.