Abstract

FORMULATION AND EVALUATION OF HERBAL EFFERVESCENT FLOATING TABLET BY USING SYZEGIUM CUMIN (JAMUN SEEDS EXTRACT) USED IN TREATMENT OF DIABETES.

Miss. Shifa A. Attar, Mr. Vishal S. Madankar, Dr. Sampat D. Navale

Abstract

The present study aimed at developing effervescent floating tablets incorporating ethanolic seed extract of Syzygium cumini (Jamun) for the sustained management of diabetes mellitus. A gastroretentive floating drug delivery system (GRDDS) was designed to enhance the residence time of the extract in the stomach and upper gastrointestinal tract, thereby prolonging hypoglycemic activity. (Jamun) for the sustained management of diabetes mellitus.Jamun (Syzygium cumini) seeds have been widely recognized in traditional medicine for their potential to support diabetes management. They contain phytochemicals such as gallic acid, ellagic acid, quercetin, and kaempferol, which contribute to blood glucose regulation, enzyme inhibition, and antioxidant activity. Formulation of Jamun seed extracts into standardized tablets provides a convenient dosage form that improves stability, accuracy, and patient compliance. Experimental studies indicate that these tablets can lower fasting blood glucose, enhance insulin sensitivity, and protect against oxidative stress. Clinical findings further suggest their ability to improve long-term glycemic control. This review discusses the phytochemistry,mechanisms of action, formulation techniques, evaluation methods, and clinical perspectives of Jamun seed tablets, highlighting their potential role as natural diabetic agents.

Keywords: Antidiabetic, Flavonoid, phenolic, polyphenol, hypoglycemic.