Abstract

FORMULATION AND EVALUATION OF DITHRANOL PRONIOSOMES FOR TREATMENT OF ACNE AND PSORIASIS

Simran Thakur*, Rajkumar Mishra, Dr. Bhanu P. S. Sagar

Abstract

The work's objective was to formulate and describe dithranol niosomal gel, put it into an appropriate dermatological basis, and evaluate its relative effectiveness in treating acne and psoriasis infections. DTL was discovered to have UV absorption maximums (λmax) of 254, 287, and 354 nm and possess a melting point of 1780C. In compatibility studies, it was discovered through FTIR spectral analysis that the absorption maxima of functional groups in both the pure drug DTL and the drug polymer/stabilizer/gelling agent mixture did not change. Then, different ratios of surfactant, lecithin, cholesterol, drug, Carbopol 934 (gelling agent), and ethanol were employed to manufacture vesicular proniosomes of dithranol (DTL) using the coacervation phase separation method. The formulated proniosomes had a lamellar vesicular structure, and the carrier had vesicular properties, according to SEM and TEM visualisation. Vesicle size reduces as the surfactant's hydrophobicity increases (since surface energy falls with increased hydrophobicity). Because Span 40 and Span 60 were combined with soy lecithin and cholesterol, formulation R4 had the highest entrapment efficiency (95.92%). DTL was released in the following order in several formulations: R1, R2, R4, R3, R5, and R6. After 30 hours, the R1 formulation had the highest drug release (85.11%) and the R6 formulation had the lowest drug release (76.25%), according to this drug release order of several formulations. The in-vitro release of DTL from proniosomal formulations increased significantly as the alkyl chains of different Spans decreased. DTL was found to be released from R1, R2, R3, R4, R5, and R6 formulations at rates of 83.27%, 81.65%, 76.79%, 82.28%, 76.51%, and 73.11%, respectively. The most effective proniosomal formulation was R1. The presence of phenolic hydroxyl groups is the primary cause of DTL's antioxidant activity. Dithranol proniosomal specialised formulations were found to be effective in treating acne and psoriasis.

Keywords: Carbopol 934, dithranol, cholesterol, lecithin, drug, proniosomal, surfactant.