Abstract

DEVELOPMENT AND EVALUATION OF ADVANCED NANOSPONGES BASED MELOXICAM GEL FOR PROLONGED ANTI-ARTHRITIC ACTIVITY

Tanvi I. Ambhire*, Dr. Avish D. Maru, Jayshree S. Bhadane

Abstract

Recent advances in nanotechnology have led to the development of a targeted drug delivery system. To successfully target a molecule to a target region, however, a specific medicine delivery technique is required. Furthermore, the NS has been used to improve the solubility and rate of dissolution of poorly soluble drugs. Nanosponges with controlled release properties can reduce drug toxicity by improving their stability and half-life. They are a biodegradable, three-dimensional network that releases the drug when the body progressively breaks it down. The NS particles move throughout the body until they arrive at a certain location, stick to surfaces, and begin releasing the drug in a controlled and predictable manner. Nanotechnology and nanomedicines, as a large field of study, offer solutions to a variety of unsolved therapeutic and pharmaceutical difficulties with delivery. Because they prolong the release of pharmaceuticals and solubilize poorly water-soluble drugs, nanosponges are the most widely used dosage form based on nanoparticles. Nanosponges are extremely tiny, nanoscopic particles that resemble sponges and are composed of several drug-filled chambers. Arthritis is an autoimmune disease that causes inflammation in the body's tissue that is damaged. Nanosponge gel may be useful in the treatment of arthritis. It ensures controlled and prolonged drug release in addition to outstanding stability. Because of their aqueous solubility, nanosponges can be used successfully for medications with lowsolubility. To target systems for delivering drugs, nanosponges can be applied topically. When situated side by side, nanosponges porous structure provides it a special capacity to capture drugs and provide the best release rate. When applied topically, it reaches the site of action, sticks to the receptor site, and releases the drug in a consistent and desirable manner. The components, preparation methods, characterization, and uses as a drug delivery system in the field of nanotechnology are all covered with this study.

Keywords: Meloxicam, Topical Nanosponges formulations, Arthritis management, Drug delivery, Inflammation, Drug encapsulation, Controlled drug release.