Abstract

ANTI-ARTHRITIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACTS OF TINOSPORA CORDIFOLIA WILLD. AND CALOTROPIS GIGANTEA LINN BY IN-VITRO METHOD

Ms. Madhu Gobbur, Ms. Bhavana Girame, R. Y. Patil*, Ms. Devyani Kirve

Abstract

Arthritis, particularly Rheumatoid Arthritis, is a chronic inflammatory disorder characterized by joint pain, swelling, and progressive degeneration, requiring safer and more effective therapeutic alternatives. Medicinal plants have gained attention due to their multi-targeted pharmacological actions and lower adverse effects. The present study evaluates the antiarthritic potential of hydro-alcoholic extracts of Tinospora cordifolia and Calotropis gigantea, which are widely used in traditional systems of medicine. Literature reports indicate that Tinospora cordifolia possesses significant immunomodulatory, anti-inflammatory, and antioxidant properties, while Calotropis gigantea exhibits notable anti-inflammatory and analgesic activities due to the presence of bioactive Phyto-constituents such as alkaloids, flavonoids, glycosides, and terpenoids. These phytochemicals play a crucial role in modulating inflammatory mediators and reducing oxidative stress associated with arthritis. Tinospora cordifolia showed higher inhibition of protein denaturation compared to Calotropis gigantea, while Ibuprofen exhibited maximum activity.Tinospora Cordifolia, Calotropis Gigantea, Anti-arthritic activity, Hydroalcoholic Extract, Protein denaturation assay, UV spectrophotometric method.

Keywords: Tinospora Cordifolia, Calotropis Gigantea, Anti-arthritic activity, Hydroalcoholic Extract, Protein denaturation assay, UV spectrophotometric method.