Abstract

COMPARATIVE STUDY ON SAFETY & EFFICACY OF ESCITALOPRAM VS VORTIOXETINE IN DEPRESSION DISORDER

Dr. Perumala Jasmine Joy, Dr. G. Vinod, Dr. K. Jagadeesh, Dr. K. Hari Prasad, Dr. N. M. Vageesh

Abstract

Aims: The aim of the study is comparing the safety and efficacy of SSRI’S (Escitalopram) and serotonin receptor modulator (vortioxetine) in depressive patients. Objectives: To assess the relative efficacy and safety of Escitalopram. Safety and efficacy of Vortioxetine in depressive patients. To analyse the age, gender and socio demographic data. Methodology: The study will be conducted at Maurya Hospital, Kurnool, over six months as a prospective observational study. It will involve 50- 100 patients, with data collected through patient forms and interviews. Participants must be aged 18-60, diagnosed with depression, and prescribed Escitalopram or Vortioxetine, with voluntary consent. Excluded are those unwilling to participate, on psychotropic medications, or diagnosed with schizophrenia or bipolar disorder. Discussion: A study on 60 depression patients compared Escitalopram (Group A) and Vortioxetine (Group B). Both groups had similar age and gender distributions. Group A showed higher depression severity and burnout, while Group B had slightly higher compassion scores. Both treatments significantly improved depression scores, with Group B showing greater reductions in burnout and secondary traumatic stress. The findings indicate effectiveness for both medications, with differences in psychological outcomes. Conclusion: The study compared 60 patients on Escitalopram (Group A) and Vortioxetine (Group B). Group A had higher initial depression and burnout, while Group B showed more compassion. Both groups improved in HAM-D scores, with Group A reducing burnout and traumatic stress, and Group B experiencing declines in overall quality of life scores. Both treatments were effective.

Keywords: Escitalopram, Vortioxetine, Escitalopram, Depression.