Abstract

A REVIEW ON HERBAL ANTI-ACNE TRANSDERMAL PATCH CONTAINING TURMERIC

Shivam S. More*, Mehul G. Lambhade, Shweta M. Mishra, Shruti S. Lokhande, Shailaja W. Gawande, Dr. Manisha D. Kitukale

Abstract

Transdermal drug delivery systems (TDDS) are advanced pharmaceutical formulations designed to deliver drugs through the skin into systemic circulation in a controlled and sustained manner. These systems offer several advantages over conventional oral and injectable dosage forms, including improved patient compliance, avoidance of first-pass metabolism, reduced dosing frequency, and minimized side effects. Herbal-based transdermal patches have gained increasing attention due to their therapeutic effectiveness, safety, and noninvasive nature. The present review focuses on the formulation and evaluation of a turmeric-based transdermal patch. Turmeric, scientifically known as Curcuma longa, belongs to the Zingiberaceae family and contains curcumin as its major active constituent, which possesses significant anti-inflammatory, antioxidant, and wound-healing properties. The review highlights the biological source, chemical constituents, and medicinal importance of turmeric. Soxhlet extraction using ethanol was employed for the extraction of curcumin from turmeric rhizomes. The prepared extract was incorporated into a polymeric matrix containing HPMC, plasticizers, preservatives, antioxidants, and penetration enhancers to formulate the transdermal patch. The formulation process involved solvent casting, drying, cutting, and packaging of the patches. The study emphasizes the potential of turmeric transdermal patches as an effective herbal drug delivery system with sustained therapeutic action and improved patient convenience.

Keywords: Herbal Anti-Acne Transdermal Patch, Turmeric (Curcuma longa),Transdermal Drug Delivery System (TDDS), Curcumin, Anti-inflammatory Activity, Antioxidant Activity, Wound Healing, Soxhlet Extraction, Ethanol Extraction, HPMC (Hydroxypropyl Methylcellulose),