Abstract

LIVER DERANGEMENT IN DENGUE FEVER ADMITTED IN A TERTIARY CARE HOSPITAL IN 2014, IN KOLKATA, WEST BENGAL

Dr. Ashis Kumar Saha* and Dr. Payodhi Dhar

Abstract

Dengue fever usually affects liver; it may be in mild form or may be in very severe form, latter form usually occurs in dengue hemorrhagic fever (DHF) or dengue hemorrhagic shock (DSS). This liver involvement usually occurs during the course of transient viremia. Our aim is to evaluate the grade of liver involvement with or without serosal involvement in the form of ascites or pleural effusion. In our hospital, total 404 serologically proved patients with dengue fever admitted, of which. Among them, 136 DHF and 24 DF have ALT level >75 IU/L, whereas, 65 DHF and 3 DF patients have ALT >150 IU/L. Again, among 65 DHF patients, 40, 15 and10 patients showed ALT level >150-300 IU/L, >300-450 IU/L and >450 IU/L respectively. These patients presented with signs and symptoms resembling viral hepatitis, DHF patients showed associated ascites, pleural effusion, raised INR ≥1.5, severe albuminemia. Males showed significantly raised AST >5 times than normal, AST having >75-150 and >450 IU/L, hepatomegaly, ascites. But negative viral serology helped us to diagnose these cases as hepatitis due to dengue virus infection.

Keywords: Liver involvement, Serosal involvement, Dengue fever, Dengue hemorrhagic fever, Kolkata,