Abstract

THE STUDY OF GUILLAIN BARRE SYNDROME (GBS)- A RARE BUT SERIOUS CONDITION

J. Lurdhu Mary*, Dr. Kumar Raja Jayavarapu, B. Sagar, L. Nandini, M.D. Saleha Farheen, M.D. Nazmeen, Sana, S.K. Heena Afsar, B. Divya, T. Keerthi, S. Aravind Kumar, B. Muralidhar

Abstract

Guillain -Barre syndrome (GBS) is an immune-mediated disorder of nervous system and a recognized cause of generalized progressive paralysis worldwide. The most common symptoms of GBS include Quadriparesis, paresthesia of both lower and upper limbs which is ascending in nature and difficulty in standing from sitting position. GBS is rare, incidence worldwide is estimated to be 0.6-4/100,000 person/year. The commonly recognized variants of GBS are AIDP, AMAN, AMSAN and Miller - Syndrome (MFS). In these variants AIDP is the most prevalent form and accounts for 70-90 per cent of cases. Many antecedent events of GBS Ave been identified including Cytomegalovirus infection, Campylo bacter jejune, gastroenteritis, Mycoplasma pneumonia, influenza virus and Epstein Barr virus infections. Awareness of GBS complications, their detection and management may help to prevent the morbidity rate of GBS. The diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. The common manifestations is limb weakness, more proximal than distal. This study was aimed to document the clinical findings, assess the risk factors, diagnosis and treatment pattern in variants of GBS (i.e. Acute Demyelinating Polyneuropathy (AIDP), Acute Motor Axonal Neuropathy(AMAN), and Acute Motor Sensory Axonal Neuropathy (AMSAN) among the patients with GBS during the hospital stay.

Keywords: Guillain-Barre syndrome, Acute inflammatory demyelinating polyneuropathy, (AIDP), AcuteMotor Sensory Axonal Neuropathy (AMSAN), Retro-Prospective study.