Abstract

ASSESSMENT OF TT3, TT4 AND TSH PROFILE IN CHRONIC KIDNEY DISEASE CONDITION

V. Bhavani* and V. Bhagyalakshmi

Abstract

Kidney normally is an important physiological part in the metabolism, degradation, and excretion of several thyroid hormones. It is an obvious fact that impairment in the kidney function leads to disturbed thyroid physiology. Our prime aim of the present study is to check the variations in the TT3, TT4 and TSH levels in uremia patients on regular hemodialysis and conservative treatment. The study was conducted in hospitals around Vijayawada, India. Fourty patients with no previous history of thyroid dysfunction and with varying grades of chronic renal failure were included in this study. Twenty patients were on conservative treatment and the remaining twenty patients who also had severed renal failure were on regular hemodialysis treatment (RDT). Twenty healthy peopl e we r e chos en to s e rve a s cont rol group wi th no previous history of thyroid dysfunction. In conclusion the abnormalities in thyroid function tests, including low TT3 and TT4 values are often observed in clinically euthyroid patients with chronic renal failure, these abnormalities do not appear to change significantly after the institution of regular dialysis.

Keywords: TT3, TT4, TSH, uremia, hemodialysis and hypothyroidism.