Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF NIOSOMAL DELIVERY SYSTEMS FOR ZIDOVUDINE

Shaik Harun Rasheed*, V. Sai Meghana, Rajan Kumar, Raushan Kumar, Prince Kumar, Sachin Kumar, MD. Khalilullah

Abstract

To design and optimize Zidovudine niosomes, the Thin Film Hydration Technique was employed. Niosomes have shown potential in drug release studies and may serve as an effective option for drug delivery systems. The drug is incorporated into niosomes to enhance targeting at the appropriate tissue locations. Materials and Methods: Zidovudine niosomes were prepared using the film hydration technique, with Span 20 and Tween 20 as the main components. Various parameters such as zeta potential, entrapment efficiency, and drug release profile were analyzed to identify the optimal formulation. The physicochemical characteristics were assessed using FTIR and SEM. The niosomes were further characterized for pH, viscosity, spreadability, drug content, in vitro drug diffusion, stability studies, and sterility tests. Results: The Zidovudine niosomes demonstrated high drug encapsulation efficiency and compatibility with the polymer. The formulation exhibited significant in vitro drug diffusion at 90.86% and proved to be stable in sterility tests.

Keywords: Zidovudine, Thin Film Hydration Technique, Niosomes, Novel drug Delivery System, Scanning Electron Microscopy.