Abstract

ADVANCES IN TRANSDERMAL DRUG DELIVERY: STRATEGIES TO OVERCOME THE SKIN BARRIER AND THEIR CLINICAL APPLICATION

*Divyank Agarwal, Nitin Sharma

Abstract

As the biggest organ in the body, the skin serves as a critical channel for transdermal medicinal interventions as well as a protective barrier. The field of skin-based medication delivery devices has advanced significantly in recent decades, radically changing how dermatological treatments are administered. Reduced bioavailability, delayed therapeutic onset, and systemic side effects are common problems with traditional administration techniques, such as injectable therapy and oral drugs. By enabling the direct application of medicinal substances at the intended site of action, skin-based delivery methods, on the other hand, offer a tempting option that minimizes systemic exposure and maximizes localized effects. Skin-based delivery systems have potential for treating systemic disorders that present with cutaneous symptoms in addition to their uses in dermatology. Dermatological symptoms are frequently present in diseases like rheumatoid arthritis, diabetes, and some types of cancer. Localized systemic treatment administration through the skin may offer a more effective and minimally intrusive method of treating these ailments. With a focus on the application of nanotechnology, microneedles, and other cutting-edge delivery techniques in dermatology, this review attempts to investigate the emerging subject of skin-based delivery systems for therapeutic compounds.

Keywords: Drug Administration, Transdermal Drug Delivery, Skin-Based Therapies, Nanotechnology and Therapeutic Agents.