Abstract

DEVELOPMENT AND CHARACTERIZATION OF A FLOATING DRUG DELIVERY SYSTEM FOR THE EFFECTIVE MANAGEMENT OF HYPERLIPIDEMIA

Ms. Ritu Patel*, Dr. Arun Kumar Patel, Mr. Shailendra Patel, Mr. Shivam Patel, Ms. Supriya Ojha

Abstract

Hyperlipidemia is one of the major risk factors responsible for cardiovascular diseases, affecting millions of people worldwide. Conventional oral dosage forms of antihyperlipidemic drugs often exhibit limited gastric residence time, resulting in reduced bioavailability and therapeutic efficacy. Floating Drug Delivery Systems (FDDS), classified under gastroretentive drug delivery systems, have emerged as an effective strategy to prolong gastric residence time and improve drug absorption in the upper gastrointestinal tract. The present study aims to formulate and characterize a floating drug delivery system containing an antihyperlipidemic drug to enhance gastric retention, sustain drug release, improve patient compliance, and maximize therapeutic outcomes. Various formulation approaches involving hydrophilic polymers, gas- generating agents, and controlled-release excipients are evaluated. The prepared formulations are characterized for physicochemical properties, buoyancy behavior, swelling index, in vitro drug release, release kinetics, stability studies, and compatibility using advanced analytical techniques. The optimized formulation is expected to demonstrate prolonged floating duration, controlled drug release over 12–24 hours, improved bioavailability, and better lipid-lowering efficacy compared to conventional formulations.

Keywords: Floating Drug Delivery System, Hyperlipidemia, Gastroretentive Drug Delivery, Sustained Release, Buoyancy, Controlled Drug Delivery.