Abstract

DRUGS FOR CHRONIC ALCOHOLISM AND THEIR QUANTITATIVE ESTIMATION

Rupinder Kaur* and Dr. Manish Sinha

Abstract

It is well accepted that drinking alcohol regularly for years is toxic to every tissue of our body. After consumption alcohol is metabolized by various enzymes such as alcohol dehyrogenase, catalase and cytochrome P450 to acetaldehyde in the body which leads to intoxication. Metabolic products of alcohol are responsible for the development of various diseases such as liver cirrhosis, trauma, depression etc. An alcohol addict not only keeps his health and day to day life on the line but also the family welfare's. Considering the wide nature of damage by chronic alcoholism its treatment includes not only chemotherapy but psychological therapy too. There are several drugs that decreases the alcohol craving includes acamprosate calcium, fluoxetine, disulfiram, ondansetron and naltrexone hydrochloride. The presented work provides the details of these drugs including methods of quantitative estimation in formulations, bulk drugs and in biological fluids.

Keywords: Alcohol; quantitative estimation; chronic alcoholism.