Abstract

THE CORRELATION BETWEEN SERUM TOTAL IGE AND IL-33 IN PATIENTS WITH ASTHMA AND ALLERGIC RHINITIS

Athraa K. Falhi*, Majid M. Mahmood, Suaad A. Brakhas

Abstract

The present study was aimed to correlate the levels of total IgE with the levels of interleukin-33 in patients with asthma and allergic rhinitis.Total IgE was evaluate for 195 (109 males, 86 females) patients with airway allergic disease, 120 with allergic asthma (67 males, 53 females) their mean age was 31.16±1.73 and 75 with allergic rhinitis (45 males, 30 females) their mean age was 35.28±2.31. Serum IL-33 levels was astimated for 40 asthmatic (22 males, 18 females) and 35 allergic rhinitis patients (19 males, 16 females) compared with 15 healthy individuals controls, who attended the allergy specialized center in Baghdad /Al- Resafa from October 2014 to February 2015. A high significant (P < 0.001) increase in the level of total serum IgE in asthmatic patients (328.78 ± 33.07 IU/ml), and allergic rhinitis patients (379.76 ± 36.09 IU/ml) compared to healthy individuals (81.19 ± 8.04 IU/ml). In parallel IL-33 was also recorded a significant elevation in both groups of patients (128.07 ± 13.75 pg/ml) and (144.62 ± 12.78 pg/ml) respectively. While it was (59.04 ± 9.06 pg/ml) in healthy individuals. A significant positive correlation was found between serum level of IL-33 and the total IgE.

Keywords: asthma, allergic rhinitis, total IgE, Interleukin-33.