Abstract

POTENTIAL EX-VIVO CARDIOPROTECTIVE EVALUATION OF LEAVES OF P. BEDDOMEI

Md. Reyad-ul-ferdous*, DM. Shamim Shahjahan, Md. Munirul Islam Tanvir, Shamsunnahar Sumi, Mohammad Shahin Alam, Md. Irfan Amin Chowdury

Abstract

The crude methanolic extracts of leaves of Parathelypteris beddomei and its different organic soluble partitionates were screened for thrombolytic activity for isolation of cardioprotective drugs. The various extracts of Parathelypteris beddomei were tested to know the activity against lysis of human erythrocyte clot formation. All extracts exhibit mild to moderate thrombolysis activity. methanolic soluble fraction 13.47%, chloroform soluble fraction 19.55%, aqueous soluble fraction 18.56%, pet ether soluble fraction 10.94%, and carbon tetrachloride soluble fraction 13.18%, whereas standard and blank exhibit lysis 65.16% and 5.79% respectively. Further studies may lead to isolation, purification of lead compounds for treatment of various diseases.

Keywords: Parathelypteris beddomei; Cardioprotetive, Biological Investigation.