Abstract

FORMULATION DEVELOPMENT OF BCS CLASS II DRUGS EMPLOYIG CYCLODEXTRIN COMPLEXATION – A REVIEW OF RECENT RESEARCH

K. P. R. Chowdary* and M. Gowthami

Abstract

BCS class II drugs pose challenging problems in their pharmaceutical product development process because of their low solubility and dissolution rates. They require enhancement in solubility and dissolution rate in their formulation development especially solid dosage forms such as tablets and capsules. Several conventional methods and new emerging technologies have been developed for formulation development of BCS class II drugs. These methods and literature on cyclodextrin complexation along with recent research work on cyclodextrin complxation is reviewed in this article.

Keywords: BCS class II drugs, Formulation development, Cyclodextrin complexation, Recent research.