Abstract

ANTIDIAROHEAL ACTIVITY OF THE WHOLE PLANT OF TINOSPORA CORDIFOLIA

Deepak Gahlawat*, Charan Singh, Geeta, Tarun Virmani, Jyoti Gupta, Reshu Virmani

Abstract

Tinospora cordifolia (Family Menispermaceae) is commonly known as Amrita (Guduchi, Giloya). It is widely used by tribals for the treatment of various infectious diseases. The aim of the present study was to determine the antidiarrheal activity of methanolic extracts of the whole plant of Tinospora cordifolia. The castor- oil induced diarrhea model were used for the study. Animals were divided into different groups control, standard, and test group after IAEC approval. Final results of different groups were compared (results of the extract (200 mg/kg, 400 mg/kg) with that of standard drug (Lopramide 3 mg/kg). On the basis of experimental data obtained, it was observed that the whole plant extract at the dose of 200mg/kg and 400mg/kg showed significant antidiarrheal activity and the activity was found to be maximum at 400mg dose extract. It means that the effect was found to vary in a dose dependent way. The result suggests that the methanolic extract from the whole plant of Tinospora cordifolia exhibited significant dose dependant antidiarrheal activity.

Keywords: Tinospora cordifolia, Lopramide, Antidiarrheal, Castor- oil.