Abstract

SYNTHESIS AND FORMULATION OF NEW FUNCTIONALIZED CITRIC ACID BASED DENDRIMERS FOR DRUG DELIVERY USING AN ANTI BACTERIAL AGENT

*B. Narasimha Rao, V. Viswanath, M. Purushothaman, V. Prasanna Vaishnavi

Abstract

The aim of the study is to synthesize G1, G2, G3, G4, G5 citric acid dendrimerse for targeted release by using an anti bacterial drug. The citric acid dendrite structure was synthesized and characterized by using IR. Clindamycin Hcl an anti bacterial drug is effective to both aerobic gram+ve and anaerobic gram –ve bacteria is currently used to show its effect through citric acid. Dendrimer Clindamycin Hcl was efficiently loaded in to citric acid dendritic structure using dissolution process. Entrapment of Clindamycin Hcl drug into the citric acid dendrimer for safe and specific targeting of the drug in to the cells. Drug loaded dendrimers were assessed with their physicochemical properties such as UV, IR, SEM, drug loading and invitro release study of the drug were evaluated.G5,the optimized formulation have to be evaluated for toxicity to ensure the safety and efficacy of dendrimer.

Keywords: Noveldrugdelivery, Citricacid, Clindamycin HCL, Dendrimer, DMF (dimethyl formamide).