Abstract

FORMULATION AND EVALUATION OF MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE BY SOLID DISPERSION METHOD

Senthil Kumar Krishnan*, Gummadi Ashwini, Dr. Mohammed Gulzar Ahmed

Abstract

The aim of the study was to improve the solubility and dissolution rate of the drug Verapamil HCL using solid-dispersion-Sustained release matrix tablets by direct compression method. Solid dispersions were prepared by solvent evaporation technique using PEG 6000 poloxamer 188 and Urea as carriers. The solid dispersions were characterized by using FTIR and confirmed that no chemical interaction during entrapment process. The prepared solid dispersions were formulated in matrix tablets evaluated for pre-compression and post-compression parameters. The post compression parameters were evaluated for hardness, friability, weight variation and drug content which were within the acceptable official limits. The drug content was found to be high and uniformly distributed in all formulations. It was shown that with the developed formulations, the release and dissolution of drug from the tablets can be increased by formulating it as solid dispersion tablets. It was concluded that development of sustained release solid-dispersion tablets using poloxamer 188 [97%] with HPMC K4m results highest increase in dissolution rate and optimum rate of drug and reduced crystallinity of Verapamil HCL can account for the faster dissolution of the released drug from the polymer matrix.

Keywords: Verapamil Hcl, Poloxamer-188, solid dispersion, solvent evaporation method, Dissolution, SD-SR.