Abstract

WOUND HEALING ACTIVITY OF PROSOPIS JULIFLORA LINN.

Thirupathy Kumaresan P*, Deepa M., SirrajudeenA., Perumal P

Abstract

Prosopis juliflora is used in herbal medicine for the treatment of various diseases such as infection, pain, inflammation and wounds. The pet - ether, benzene, ethyl acetate and alcoholic extracts of Prosopis juliflora flowers were subjected to preliminary qualitative chemical investigation. Phytochemical analysis of extracts revealed that the presences of steroid, alkaloid, saponin, flavonoid and tannin in the flower parts of Prosopis juliflora. LD50 values were determined based on OCED guidelines for three extracts. The extracts did not produce any mortality even at 5000 mg/kg. The effect of pet - ether, benzene ,ethyl acetate and alcoholic extract of Prosopis juliflora flowers were investigated in rats to evaluate wound healing activity by using three models i.e incision, excision and dead space (granuloma). From the results obtained it may be concluded that ethyl acetate extract of Prosopis juliflora flowers exhibited more significant wound healing activity than other extract when compared to the reference drug ointment.

Keywords: Wound healing activity, Prosopis juliflora. Hydroxyproline.