Abstract

SYNTHESIS AND ANTICANCER SCREENING OF SOME NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES

*Dr. Suneetha T. B, Vinutha S.M, Dr. Gopinath S.M, Dr. Ismail Shareef

Abstract

The two synthetic compounds 15b and 15h is tested for their ability to prevent cervical cancer using HeLa cell line. The study shows that both 15b and 15h compounds might be useful to develop an anti-cervical cancer drug and possess potential applications in the treatment of cervical cancer. The 15h compound treatment at 100 μg/ml has significantly arrested at 62.21 % in G2M phase of cell cycle, compare to untreated cells (9.46 %). At 50 μg/ml, 15h compound has also showed good arrest at 42.89 %. This result suggests 15h compound has more effectively arrested cells at the G2 phase of the cell cycle compare to 15b. Thus both 15b and 15h compounds show more significant cell cycle arrest at G2M phase and at a same time it could induce the apoptosis in HeLa cells. These compounds can be taken up for further studies for drug development.

Keywords: HeLa cell line, Imidazole derivative, FACS.