Abstract

EFFECTS OF SILVER NANOPARTICLES IN LIVER FUNCTION ENZYMES AND OXIDATIVE STRESS LEVELS

Gulboy A. Nasir*, Hasan F. Samir and Alaa K. Mohammed

Abstract

In this study we used silver nanoparticles which have been prepared and characterized in previous study. The sliver nanoparticles were 40.5 nm in size and like spherical in shape. Three different concentrations of silver nanoparticles were injected intraperetoneally in Swiss mice (0.25, 0.5 and 1.0 mg/kg of body weight) for 7 and 14 days. The level of oxidative stress (GPx, GRx, SOD, CAT, MDA) and enzymes of liver function (AST, ALT, ALP) in serum were tested. Adverse impacts on liver function especially in activities of AST and ALP were observed in a high dose-treated group, (1.0 mg/kg).

Keywords: AgNPs toxicity, oxidative stress, liver enzymes.