Abstract

INDIAN FEMALE ARE MORE VULNERABLE FOR OXIDATIVE STRESS INDUCED CARDIOMYOPATHY: A CASE STUDY

Pradeep Bhatt* and Deepak Sharma

Abstract

Oxidative damage is known to plays an important role in the pathogenesis of diabetic cardiomyopathy. Since there is no gender based study, we aimed to evaluate the role of oxidative stress in poorly & well controlled diabetic cardiomyopathy in Indian male and female subject. Diabetic cardiomyopathic male & female subjects were categorized into 09 groups and thus blood and serum samples were examined for glycemic marker (HbA1C), oxidative marker (MDA, PCG), antioxidants (SOD, CAT, GSH, GPX), ECG and echocardiographic parameters. Results: When compared, poorly controlled diabetic group with well controlled diabetic group former showed significant cardiomyopathic changes. Female had significantly lower levels of SOD, GPX & GSH and significantly higher HbA1C, MDA, carbonyl protein (P < 0.001) than male subjects and well controlled glycemic subjects. ECG & ECHO data were significant correlation with oxidative markers in type-1 & type 2 diabetic cardiomyopathic Indian male and female subjects. Conclusion: Our data demonstrates that type-2 diabetic females are more prone for cardiomyopathy changes as compared to age matched males.

Keywords: Diabetic cardiomyopathy, Oxidative stress, Hyperglycemia.