Abstract

EVALUATION OF PLATELETS COUNT AND COAGULATION PARAMETERS AMONG PATIENTS WITH LIVER DISEASE

Mohammed Elamin Mustafa*, Mansoor Mohammed Mansoor, Asaad Mohammed Ahmed Abd Allah Babker

Abstract

We hypothesized a strong association between hemostatic changes and liver disease because hemostasis is intimately related to liver function, because most coagulation factors are protein synthesized by liver the extent of coagulation abnormalities depends upon the degree of disturbed liver function. The aim of this study was to the evaluate of Hemostatic mechanism change especially PT, PTT and PLTs count among patients with liver disease. Method: We enrolled Forty patients with liver disease (cases) include: tow gall choleystitis (5%), five obstructive jaundice (13%), ten liver cirrhosis (25%), fifteen HBV (38%), six HCV (15%) and liver metastasis (5%) those were compared them to fifteen healthy individuals as (control) group neither affected by liver diseases nor receiving any kinds of therapy that can affect in liver. Cases and controls were tested for the above investigation. Informed consent was obtained from all participants before enrolment. The automated method used to measure PT, APTT, by Coagulometer and PLTs count used (Sysmex KX 21N). Results: The PT was showed significant differences in these values between patient and control in hypertension (p= 0.01) and diabetes (p = 0.03) the no significant PT result was showed in renal failure group (p = 0.2).The APTT was tend to be prolonged in diabetes group (43.2) only the normal APTT result was showed in hypertension (40.0) and renal failure group (40.0) the statistical analysis showed significant differences in these values between patient and control in hypertension group (p = 0.01) and diabetes (p = 0.006) and renal failure ( p= 0.008).The platelet count was found to be lower in hypertension group (141.0), diabetes (147.7) and in renal failure (135.8). The statistical analysis showed significant values in all groups, in hypertension (p = 0.000) diabetes (p= 0.002) and in renal failure (p= 0.002). Conclusion: PT showed significally prolonged in all cases except renal failure, APTT showed significant among all cases and PLTs showed lower with significant value among cases. We conclude that from our study that there was a considerable association between the liver diseases and related disorder with abnormality of different haemostatic mechanism.

Keywords: Liver disease, Prothrombin, Thromboplastin, Platelets.