Abstract

ASSAY OF CLOPIDOGREL HYDROGEN SULPHATE IN TABLET FORM FROM DIFFERENT MANUFACTURING SOURCES BY USING UV SPECTROSCOPY

Zehra Ashraf*, Summaiya Khurram, Uroosa Maqbool, Kiran Raees Khan, Uroosa ajaz, Syeda Fizza Fatima, Sadia Naz, Faiza Muneer, Ummam Irfan and Maria Ayub

Abstract

The Study involves quantitative analysis or performance of assay percentage of two different brands (samples) of Clopidogrel hydrogen sulphate tablet (one is of multi industry and other is of local pharmaceuticals) by using Ultra Violet Spectroscopy. Clopidogrel hydrogen sulphate is anti-platelet drug as inhibitor of ADP & its main adverse effect is Haemorrhage. In this experimental study the samples were dissolved in distilled water & their absorbances determined at wavelength of 240nm.The result obtained were compared with that of standard. Percentage content of assay was calculated by using absorbances of samples, to see the result is in the specified limits by official limits (99%- 101.5% according to USP) & thus our Assay is 99% that is within the official limits. This shows the result is correct & thus the label claimed is also right.

Keywords: Clopidogrel hydrogen sulphate, Haemorrhage, absorbances.