Abstract

REVIEW ON COMBINATORIAL CHEMISTRY

Harpreet Kaur Khanuja*, Sagar B. Bagul, Yogesh M. Patil, Ismail R. Shaikh, Kiran R. Bhalerao and Ram M. Phad.

Abstract

In the new era of medicinal chemistry the target in focused on the preparation of chemical libraries for the generation of new lead for drug discovery. A traditional chemist can synthesize 100-200 compounds per year. Combinatorial chemistry is one of the important new methodologies developed by researchers in the pharmaceutical industry to reduce the time and costs associate with producing effective and competitive new drugs. It is used to synthesize large number of chemical compounds such as proteins & peptides by combining sets of building blocks. This review focus on various current newly available solid supports, Linkers and other accessories employed in combinatorial organic synthesis.

Keywords: Combinatorial Chemistry, Solid supports, Linkers.