Abstract

A NOVEL SYNTHESIS APPROACH OF ROSUVASTATIN AND THEIR INTERMEDIATES

Premchand B.Patil, Devanand B. Shinde, Dhananjay V. Mane, Bhata R.Chaudhari

Abstract

To development of novel and efficient strategies for their synthesis of Rosuvastatin and it is pharmaceutically acceptable salt. In the present exposure describe preparation of HMG-CoA reductase inhibitor, a novel process for the preparation of intermediates via Julia-modified olefination. That is describing here by the process which is suitable for large-scale up, environmentally benign synthesis & impurity free process that is capable of providing the drug in a cheaper and more convenient manner, which is extremely important and significant.

Keywords: Statin; Julia-modified olefination; Eco friendly synthesis; HMG-CoA reductase.