Abstract

FORMULATION AND IN VITRO EVALUATION OF CEFIXIME LIPOSPHERE

V. Ganesan* and S. Allimalarkodi

Abstract

The aim of the present study was to investigate the formulation parameters for Cefixime loaded liposphere by using lipid as a colloidal carrier. Lipid delivery system is a rapidly expanding technology forthe production of controlled release dosage form. Cefixime is frequently prescribed for various bacterial infections. An attempt was made to increase the bioavailability of sthis drug by formulating as a controlled dosage form. Melt dispersion method was selected as a formulation method in which two phases mixed together and emulsified with the help of mechanical stirrer. Cetyl alcohol, Cetostearyl alcohol and Stearyl alcohol were used as excipients, Poly vinyl alcohol (PVA) was used as stabilizer. The liposphere dispersions were characterized with respect to entrapment efficiency, loading efficiency, particle size, surface morphology and in-vitro release. Evaluation studies of lipospheres showed that shape and size of the liposphere complies with the specification of liposphere. In vitro release studies revealed the formulations all the formulations were showed controlled release form. The kinetic study revealed that the drug release followed non- Fickian release pattern. Finally the bio activity of the drug remains intact after micro encapsulation.

Keywords: Liposphere, Cefixime, In vitro drug release, controlled dosage form.