Abstract

REGULATION OF DIABETES AND OXIDATIVE ENZYMES ON SUPPLEMENTATION OF ALOE VERA EXTRACT IN LIVER ALLOXAN INDUCED DIABETIC MALE RATS.

Dr. Ravi Naik Mude*

Abstract

The present work was under taken to evaluate the oxidative Enzymes activity of Aloe vera plant extract on liver tissue oxidative Enzymes, Glucose-6-Phosphate dehydrogenase (G-6-PDH), Lactate dehydrogenage (LDH), Succinate dehydrogenase (SDH), Glutamate dehydrogenase (GDH) in Alloxan induced diabetic rats. Aloe vera leaf get extract administered orally to different groups of rat at a dose of 300 mg/kg body weight for 21 days. Three months old male wistar rats were divided into 4 groups (n=6) namely: Control, control + Aloe vera, diabetic (Alloxan 40mg/kg body weight), diabetic + Aloe vera (300 mg/kg body weight). G-6-PDH, SDH, GDH, activities were decreased in diabetic rats. Whereas LDH activity was increased. Oral administration of Aloe vera leaf extract to diabetic rats showed significant reversal of disturbed oxidative enzyme system. The findings of the present study suggest that oxidative stress starts at Type-I diabetes mellitus and increases progressively. In conclusion, the Aloe vera extract played a key role in reduction of diabetes for diabetic patients.

Keywords: Diabetes, Aloe vera, Alloxan, Oxidative stress, Rats.