Abstract

ESTIMATION OF WITHDRAWAL PERIOD OF CIPROFLOXACIN IN LIVER AND BREAST MUSCLE OF DUAL PURPOSE CHICKEN

Sunil Chandra U.*, Shridhar N.B., Jagadeesh S., Sanganal, Narayanaswamy H.D., Ansar Kamran C. and Ramachandra S.G.

Abstract

The study was carried out to evaluate the withdrawal period of ciprofloxacin in liver and breast muscle tissues of dual purpose chicken after oral administration for five days. Indian Rock -3, a dual purpose chicken strain of White Plymoth Rock developed by Karnataka Veterinary Animal Fisheries Sciences University, Bidar was used for the study. Birds in the age group of thirty days, were divided in to two groups. Group I (n=10) birds served as control, did not receive any drug. The tissue samples of these were used for the standardization of the analytical instrument. Group- II (n=80) birds received ciprofloxacin at 8mg per kg body weight orally for five days. Residue analysis in liver and breast muscle were analysed by liquid chromatography-mass spectrometry (LC-MS). The residue concentration of ciprofloxacin was gradually decreased in chicken liver and breast muscle samples starting from day one to day ten after the last dose. Ciprofloxacin was estimated to have a pre slaughter withdrawal period of four to five days in comparison with maximum residue level of 200, and 100 μg / kg for liver and breast muscle. respectively as per European economic community council regulations..

Keywords: ciprofloxacin, LC- MS, liver, breast muscle, maximum residue limit.