Abstract

A REVIEW: NOVEL APPROACHES OF COLON TARGETED DRUG DELIVERY SYSTEM

Warsha Pant*, Ashutosh Badola, Shweta Baluni, Shailaja Pant

Abstract

The colonic drug delivery has gained importance for drug delivery for local disease treatment associated with colon and included systemic delivery of protein and therapeutic peptideanti-asthmatic drugs, antihypertensive drugs. Colon is site for local and systemic delivery of drugs. For the treatment of inflammatory bowel disease such as crohn‟s disease, colon cancer, amobebiasis, ulcerative colitis by topical and systemic delivery colon targeted drug delivery system (CDDS) is an promising tool. CDDS cause lower the systemic side effects. On the disease site lowers the requirement of higher dose of drugs thus cause in reducing the drug cost and frequency of dosage. If the drug to be delivered directly to colon than the treatment should be more effective. This review also focuses on the novel approaches as pressure controlled colonic delivery, CODESTM, osmotic controlled drug delivery.

Keywords: peptideanti-asthmatic, amobebiasis, crohn?s disease, colon cancer.