Abstract

TERNARY SOLID DISPERSIONS OF OMEPRAZOLE FOR ENHANCING SOLUBILITY AND DISSOLUTION.

Arshad Ahmed Khan K.*, Aparna.P, Harathi.P, Padmanabha Reddy.Y, Sowmya.C

Abstract

Omeprazole, is widely used in the treatment of acid, peptic disorders and duodenal ulcers. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. Therefore to increase its aqueous solubility ternary solid dispersions (TSD) of omeprazole were prepared by solvent evaporation method, using hydrophilic carriers like polyvinyl pyrrolidone (PVP), hydroxyl propyl methyl cellulose (HPMC), and solubilizer sodium lauryl sulphate (SLS). Eight formulae were prepared and evaluated for drug content, solubility, In‐vitro drug release and dissolution efficiency. Solid state characterization including FTIR and XRD is also carried out. All formulae showed marked significant improvement in the solubility and dissolution rate of the drug. Solubility studies indicated that PVP along with SLS significantly increased the solubility as well as the bioavailability of omeprazole by 14.66 folds. The interaction studies showed no interaction between the drug and any of the used carriers. In‐vitro release profiles of all dispersions were comparatively evaluated and also studied against pure omeprazole. Faster dissolution with greater dissolution efficiency was exhibited by ternary solid dispersion (F7) containing omeprazole: PVP: SLS in 1:1:0.75 ratios. The cumulative release of omeprazole from formulation F7 was 98.15% within 60 min and was 4.48 times higher than the pure drug in 0.1N HCl. The increase in dissolution rate of omeprazole by ternary dispersion technique may be due to increase wettability and hydrophilic nature of carrier.

Keywords: Omeprazole, ternary solid dispersion, solvent evaporation method, Solubility.