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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

EFFECT OF TARTRAZINE ON ACID AND ALKALINE PHOSPHATASES IN THE LIVER OF ALBINO RATS

Veena B. Kushwaha* and Geeta Bharti

Abstract

Tartrazine (E102, Trisodium (4E)-5-oxo-1-(4-sulfonatophenyl)-4-[(4- sulfonatophenyl) hydrazono]-3-pyrazolecarboxylate) is a synthetic lemon yellow azo dye, water soluble and commonly used as food coloring agent all over the world. Hence, this study is aimed on estimation of the variation in the activity of enzyme acid and alkaline phosphatase in the liver of both male and female albino rats after exposure to sub lethal oral doses (100, 200 and 400mg/kg body weight) for 28 days. A non-significant increase in the activity of acid phosphatase after 7 and 14 days, while a significant (p

Keywords: Food additive, Color additive, Tartrazine, Hepato-toxicity, Acid Phosphatase and Alkaline Phosphatase.

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