Abstract

CALLISTEMON CITRINUS (CURTIS.) LEAF SHOWS ANALGESIC AND ANTIDIARRHEAL ACTIVITIES IN SWISS-ALBINO MICE MODEL

Farhana Ahmed, Mohammad Firoz Khan, Sharmin Reza Chowdhury, Mohammad Sharifur Rahman, Md. Al-Faruk and Mohammad A. Rashid,*

Abstract

Callistemon citrinus (Curtis.) is an evergreen shrub that grows in Bangladesh. In order to explore the medicinal potentials, the leaves of this plant were investigated in Swiss albino mice model. The collected leaves were extracted with methanol and assayed for analgesic activity in Swiss-albino mice model by acetic acid-induced writhing and tail immersion methods. The antidiarrheal assay was also performed against castor oil-induced diarrhea. The extract when administered to the mice orally at 200 and 400 mg/kg body weight exhibited significant analgesic and antidiarrheal activities as compared to the controlled groups. This is the first report for analgesic and antidiarrheal activities of the leaves of C. citrinus.

Keywords: Callistemon citrinus, Myrtaceae, Analgesic, Antidiarrheal, Acetic Acid, Castor Oil, Writhing, Tail Flicking.