Abstract

PHYTOCHEMICAL AND BIOLOGICAL EVALUATION OF ALBIZIA RICHARDIANA BENTH, FABACEAE FAMILY

Monica Sharfin Rahman, Hosne Jahan Shetu, Abhijit Sukul*and Imon Rahman

Abstract

This dissertation aimed to investigate and evaluate the possible phytochemical and biological profiles like, phytochemical screening, antioxidant, antimicrobial, cytotoxic and hypoglycemic activities of the medicinal plant Albizia richardiana (Fam. Fabaceae, subfam. Mimosoideae). Phytochemical screening test of the methanolic plant extract of Albizia richardiana suggests the presence of bioactive substances like- carbohydrates, saponin, glycosides, glucosides, alkaloids in the bark extract of plant. Antioxidant activity was screened using DPPH assay and ethyl acetate soluble partitionate of bark revealed the significant free radical scavenging activity with IC50 values of 17.8 μg/ml as compared to standard, butylated hydroxyl toluene (IC50 11.62 μg/ml). In the brine shrimp lethality bioassay, the chloroform soluble extractive from bark showed cytotoxicity (LC50 = 22.03 μg/ml) as compared to vincristine sulfate (LC50 = 0.52 μg/ml). Significant hypoglycemic activity was observed after 60 and 120 minutes of administration. No significant antimicrobial was observed from this plant part. Chemical investigation of the bark extract of Albizia richardiana, for the first time from this plant. This is the also the first report of the bioactivities of this plant.

Keywords: Antioxidant activity, Phenolics, Flavonoids, Terpenoids, Saponins, Cytotoxicity.