Abstract

CHANGES IN SERUM IGE LEVELS BEFORE AND AFTER IMMUNOTHERAPY IN PATIENTS WITH ALLERGIC AIRWAY DISEASES

Athraa K. Falhi*, Majid M. Mahmood, Suaad A. Brakhas

Abstract

The present study was aimed to assess the effects of allergen immunotherapy on total IgE in patients with asthma and allergic rhinitis. Allergen immunotherapy involves the repeated administration of specific allergen to patients with IgE mediated conditions in order to induce immunologic tolerance to the offending allergen. Total IgE was evaluate for 100 patients, 54 with allergic asthma (29 males, 25 females) their mean age was (33.28 ± 1.54) years, and 46 with allergic rhinitis (24 males, 22 females) their mean age was (33.46±2.55) years, who attended the allergy specialized center in Baghdad / Al- Russafa from October 2014 to February 2015. The effects of allergen immunotherapy on total IgE were assessed by comparing levels of this immunoglobulin before received immunotherapy and after received for at least six months. The levels of total IgE recorded to be significantly regressed in sera of both groups of asthma and allergic rhinitis patients to reach respectively (216.03 ± 42.41 IU/ml) and (203.98 ± 14.87 IU/ml) after they are (328.78 ± 41.65 IU/ml) and (379.76 ± 62.96 IU/ml) before receiving allergen immunotherapy.

Keywords: asthma, allergic rhinitis, total IgE, allergen immunotherapy.