Abstract

A REVIEW ON OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM

Nitin D. Umbarkar*, Nitin P. Kanwale, Rohit H. Bhaskar, Sudhir D. Khatal, Datta P. Gavali.

Abstract

This paper reviews constructed drug delivery systems applying osmotic principles for controlled drug release from the formulation. Osmotic devices which are tablets coated with walls of controlled porosity are the most promising strategy based systems for controlled drug delivery. In contrast to common tablets, these pumps provide constant (zero order) drug release rate. When these systems are exposed to water, low levels of water soluble additive is leached from polymeric material i.e. semipermeable membrane and drug releases in a controlled manner over an extended period of time. The main clinical benefits of oral osmotic drug delivery system are their ability to improve treatment tolerability and patient compliance. These advantages are mainly driven by the capacity to deliver drugs in a sustained manner, independent of the drug chemical properties, of the patient’s physiological factors or following food intake. This review brings out the theoretical concept of drug delivery systems, osmosis, principle of osmosis, historical background, advantages and disadvantages of the delivery system, basic component of osmotic drug delivery, classification of osmotic system, factors affecting the drug delivery system, conclusion and marketed products.

Keywords: Osmotic drug delivery system, Osmosis, Semipermeable membrane, Control drug delivery system, component of osmotic system.