Abstract

A REVIEW ON MICROSPHERE AS A NASAL DRUG DELIVERY SYSTEM

Manjusha Bhange*, Vijaynanda Khadkutkar, Aparark Moholkar, Ranjana Suryawanshi, Vitthal Lingayat, Radha Jadhav, Sandip Gapat.

Abstract

“The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration. A well designed controlled drug delivery system can overcome some of problems of conventional therapy and enhance therapeutic efficacy of the given drug. There are various approaches in delivering therapeutic substance to the target site in sustained and controlled release fashion”. The microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, which are biodegradable in nature, and ideally having a particle size less than 200μm. Solid biodegradable microspheres incorporating a drug dispersed or dissolved throughout particles matrix have the potential for the controlled release of drug. The nasal mucosa has also received attention as a viable means of systemic administration of analgesics, sedatives, hormones, cardiovascular drugs, and vaccines. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body. Approaches are discussed here for increasing the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption. The article highlights the importance and advantages of the nasal drug delivery systems. mucoadhesive systems have been prepared for both oral and peroral administration in the past. The nasal mucosa presents an ideal site for bioadhesive drug delivery systems. In this review we discuss the effects of microspheres and approaches also method of preparations with future opportunities of microsphere in nasal drug delivery system.

Keywords: Nasal Drug Delivery System, polymers, absorption mechanism, method of preparation, future opportunities.