Abstract

INCIDENCE OF CHROMOSOMAL ABERRATIONS BY DOXORUBICIN AND ITS PROTECTION BY AEGLE MARMELOS

Prabhakar Reddy Ch, *Rudrama Devi K. and K. Pratap Reddy

Abstract

Adriamycin (ADR) (doxorubicin) is one of most effective chemotherapeutic agents and is the most commonly used anthracyclin antibiotic effective in treatment of various cancers. Adriamycin induces mutations and chromosomal aberrations in normal and tumor cells. Adriamycin has high affinity for cell nuclei and about 60% of total intracellular adriamycin is found in cell nucleus and binds to DNA polymerase and inhibits synthesis of nucleic acid and protein, results in DNA damage and free radical formation. As Adriamycin is widely used, it is important to reduce its toxicity to normal cells which can be achieved by concurrent administration of antioxidants. Herbs are gaining additional focus because of their less toxicity and high efficacy against a number of ailments. has been used Aegle Marmelos extract for broad spectrum of diseases and its isolated compound Aegle Marmelos extract found to be anticarcinogenic and a potential antioxidants. In the present investigation studies were carried out to observe the efficacy Aegle Marmelos fruit extrac(tAMFE) of against Adriamycin induced cytogenetic damage in bone marrow cells of mice. The animals treated with 10mg/kg, 15mg/kg and 20mg/kg of showed Aegle Marmelos fruit extract to be non mutagenic. Aegle Marmelos extract shows protective effects against the adriamycin induced genotoxicity in bone marrow cells of mice. Hence Aegle Marmelos fruit extract C supplementation is safer in chemotherapeutic s Aegle Marmelos trategy.

Keywords: aeges marmelus extract, Adriamycin, Micronuclei, Bone marrow cells.