Abstract

PROTECTIVE EFFECTS OF GARLIC EXTRACT ON CYCLOPHOSPHAMIDE INDUCED GENOTOXICITY IN SWISS MICE

Sri Vani S., K. Rudrama Devi* and P. P. Reddy

Abstract

In the present investigation the antimutagenic effects of Garlic extract has been evaluated against cyclophosphamide induced genotoxicity in bone marrow cells of mice. Single IP administration of garlic extract at various doses i.e. 125, 250 and 500 mg /kg. When treated individually did not induce chromosomal aberrations in somatic cells of mice. A single Intra peritoneal injection of 50mg/kg of cyclophosphamide induced significant increase in the percentage of micronuclei in bone marrow cells of mice. However after co administration of three doses of garlic extract there was a dose dependent decrease in the % of chromosomal aberrations was observed. Thus the results clearly indicate the protective effects of garlic extract against cyclophosphamide induced genotoxicity in bone marrow cells of mice. Therefore the data indicate that Garlic extract is a safer dietary component in cancer chemo preventive strategy.

Keywords: Garlic extract, Cyclophosphamide, chromosomal aberrations.