Abstract

DOCKING ANALYSIS AND SYNTHESIS SOME NEW 1-(4-ETHYLPHENYL)- 2-(5,5-DISUBSTITUTED-4-HYDRO-[1,3,4]OXADIAZOLE-2- YL)-ETHANONE AS IMPENDING ANTI-DIABETIC AGENTS

Jhilika Singh*, Arvind Kumar and Vaishali

Abstract

A new series of 2-[5-substituted phenyl-5-alkyl-4-hydro-[1,3,4] Oxadiazole-2-yl]-1-(4-ethyl-phenyl)-ethanone derivatives were synthesize by the esterification reaction of 4-(4-Ethyl-phenyl)-4-oxobutyric acid with H2SO4 and ethanol. Followed by hydrazine hydrate to give substituted hydrazides and then hydrazone with substituted ketons, which were cyclise with chloramines-T to give the 2-[5- substituted phenyl-5-alkyl-4-hydro-[1,3,4]-Oxadiazole-2-yl]-1-(4- ethyl-phenyl)-ethanone derivatives. All these compounds were evaluated for in-silico anti-diabetic activity (docking on Glycogen Phosphorylase B protein) and also screened in-vivo anti-diabetic activity by alloxan induce diabeties mellitus model. All compounds were characterized by FT-IR, 13CNMR, 1HNMR and elemental analysis (CHNO). The titled compound exhibited good binding property with molecular target. Some of the compounds have shown good anti-diabetic activity and few have shown moderate anti-diabetic activity as compared to the standard drug.

Keywords: 1,3,4-Oxadiazole, Docking, Anti-diabetic Activity.