Abstract

A COMPARATIVE STUDY OF ANTIDEPRESSANT EFFECT OF AGOMELATINE WITH FLUOXETINE IN MICE

*Chaudhary K. Pankaj, Dr. Jain Atul, Dr. Gaur Vikas, Dr. Maurya k Arvind, Dr. Neeraj Rajdan and Dr. Gaurav

Abstract

Objective: To compare antidepressant effect of Agomelatine with Fluoxetine in mice. Background: A comparison of Agomelatine with Fluoxetine in mice has not much been performed, the other antidepressant in the same therapeutic class with a significant market share, has been undertaken. Agomelatine is a new antidepressant with selective agonist actions at melatonin receptors and selective antagonist action at serotonin 5HT-2C receptors. It does not affect the uptake of serotonin, nor adrenaline or dopamine. In the absence of relevant data to assess the place that Agomelatine should occupy in the therapeutic arsenal, indirect comparisons are the most rigorous way to go. We conducted a study evaluate antidepressant of Agomelatine with Fluoxetine in Swiss albino mice. Materials and Methods: Agomelatine (50mg/kg body weight, i.p) was administered once daily for 14 days to Swiss albino mice of either sex. The immobility period for antidepressant activity of mice were recorded in Forced swim test (FST) and Tail suspension test (TST) of the control, standard and Test drug treated group. The antidepressant activity of Agomelatine was compared to that of Fluoxetine (20mg/kg, i.p.) administered for14 days. Results: According to the results obtained from FST and TST for antidepressant, with regard to the experiments performed, all the evidence pointed to the conclusion that the antidepressant effect of Agomelatine was more than the control group and Fluoxetine. Based on the results of the FST, TST Agomelatine has favorable antidepressant on mice as compared to the Fluoxetine treated and the control groups and the better effects were seen by increasing duration of drug use. Conclusion: It can be concluded that Agomelatine is a better drug in case of depression compared to Fluoxetine in mice.

Keywords: Antidepressant effects; Agomelatine; Fluoxetine; FST; TST.