Abstract

CARBIMAZOLE INDUCED AGRANULOCYTOSIS WITH HYPOTHYRIODISM – A CASE REPORT

Sandeep Ankam*, Manasa Bollampally, Pravallika Guttu, Dr. Ramya Bala Prabha, Sharadha Srikanth, Dr. Uma Maheswara Rao.V

Abstract

Agranulocytosis is a rare adverse effect of anti-thyroid drugs; the reported incidence being ~0.17%-0.23%. Agranulocytosis has been reported with all antithyroid drugs including Propylthiouracil, Methimazole and Carbimazole. Drug-induced agranulocytosis can be caused by direct marrow toxicity or be immune mediated. The antithyroid drugs Carbimazole (Neo-Mercazole) and Propylthiouracil carry a relatively high risk of haematological dysfunctions including agranulocytosis. Females and those aged over 65 may have an increased risk. Patients taking antithyroid drugs should be told to notify their doctor at once if they experience fever, a sore throat, mouth ulcers, bruising, malaise or nonspecific illness. Because these are the complications associated with the use of antithyroid drugs and such reports should be treated as medical emergencies.

Keywords: Drug-induced agranulocytosis, Antithyroid drugs, Carbimazole.