Abstract

A FACILE SYNTHESIS OF BIO ACTIVE 2-AZETIDINONES DERIVATIVES AND THEIR PHARMACOLOGICAL ACTIVITY

Kokila A. Parmar*, Chetan J. Vasava and Sarju N. Parajapati

Abstract

An expeditious method for preparation of azetidine-2-ones 7(a-h) are an important class of heterocycles, having potential biological importance due to their unique features. The process of convert of imine (Schiffs base) to azetidine (β-lactam) through an intermediate of monochloro acetyl chloride is important synthetic method for preparation of azetidine-2-ones. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, 13C NMR and Mass spectral studies. The compounds were screened for their antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Esherichia coli and Pseudomonas aeruginosa was determined by disc diffusion technique. All the synthesized compounds exhibited promising antimicrobial activity against the studied set of microorganisms. However, the activity was less than that of standard drugs used in this study.

Keywords: 2-Aminobenzothiazole, azetidinones, Schiff base, antibacterial activity.