Abstract

CASE REPORT ON CLOZAPINE INDUCED SEIZURE

Greeshma Hanna Varghese*, Hanna Alexander, Swethalekshmi V., Neethu Ros Tom, T. R. Ashok Kumar, Dr. T. Sivakumar

Abstract

Clozapine is a widely used atypical antipsychotic with a unique effectiveness in treatment-resistant schizophrenia. An important adverse effect is seizures, which have been observed at all stages of clozapine treatment. Compared with standard neuroleptics clozapine has minimal extra pyramidal side effects and poses a low risk for tardive dyskinesia. Most drug induced seizures resolve after discontinuation of the offending drugs, but some patients require supplementary treatment. Valproate has traditionally been considered the drug of choice for the prophylaxis of clozapine induced seizure.

Keywords: clozapine, seizure, adverse drug reaction.