Abstract

A REVIEW ARTICLE ON MUCOADHESIVE MICROSPHERE AS A CONTROLLED DRUG DILIVERY SYSTEM

Abhishek Mishra* and Vandana Singh

Abstract

Microspheres are spherical powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive microspheres provide a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and improve or better therapeutic response of the drug. Mucoadhesion while considering drug delivery is having several merits, because of the ideal physiochemical characters of the mucosal membrane. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. Mucoadhesive microspheres deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of action. Several synthetic and natural polymers are identified as suitable candidates for mucoadhesive formulation. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs.

Keywords: Microspheres, controlled release, Mucoadhesion.