Abstract

LIPID LOWERING EFFECTS OF SOME PLANT SEEDS, BARK AND HONEY IN HYPERLIPIDAEMIC ALBINO MICE

Abstract

Effect of the mixture containing ajowain, kalonji, daarchini, apple vinegar and honey was investigated in hyperlipidaemic albino mice. Mice were grouped and maintained for 60 days as (I) untreated control on normal routine feed; (II) untreated control on atherogenic diet; (III) treated control on synthetic cholesterol lowering drug Tablets Survive® (Simvastatin 20mg) while (IV), (V) and (VI) served as treated control on three respective doses of experimental mixture. Results revealed that administration of atherogenic diet lead to an increase in serum lipid parameters like total cholesterol, triglycerides, total cholesterol and LDL-cholesterol while the administration of different doses of mixture significantly showed a graded reduction in all the serum lipid parameters with an increase in HDL-cholesterol levels, respectively. It was concluded that atherogenic diet resulted an increase in serum lipid levels, causing hyperlipidaemia, which could be reduced by the mixture at dose rate of 3.5 ml/Kg BW. Antihyperlipidaemic activity of simvastatin and mixture at dose rate of 3.5 ml/Kg BW was found to possess almost similar antihyperlipidaemic activity at post treatment day 60 in hyperlipidaemic mice.

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