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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

BIOLOGICAL ACTIVITY OF 3-ARYLIDENE-5(SUBSTITUTED PHENYL)-1- BENZYL-2(3H)-PYRROLONE DERIVATIVES

Shah Alam Khan, Aftab Ahmad, Asif Husain*

Abstract

The present study aimed to investigate the in vitro anthelmintic activityof 1-Benzyl-2(3H)-Pyrrolone derivatives against two species ofearthworms i.e. Pheretima posthuma and Perionyx excavatus. Theanthelmintic activity of eleven benzyl pyrrolone derivatives wasdetermined by recording the mean paralyzing and death times of theworms at concentration of 2mg/mL. The screened compounds showedpromising anthelmintic activities against both types of worms and theresults were comparable to positive control albendazole.

Keywords: Benzyl pyrrolone, Pheretima posthuma, Perionyx excavatus, Anthelmintic.

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